Cxcr3^tm1Wwh
Targeted Allele Detail

Summary

• Symbol: Cxcr3^tm1Wwh
• Name: C-X-C motif chemokine receptor 3; targeted mutation 1, Wayne W Hancock
• MGI ID: MGI:2180682
• Synonyms: Cxcr3^-, CXCR3-, CXCR3-KO
• Gene: Cxcr3 Location: ChrX:100775141-100777753 bp, - strand Genetic Position: ChrX, 44.58 cM
• Alliance: Cxcr3^tm1Wwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65916
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 800 bp of exon 2 was replaced with a PGK-neo cassette via homologous recombination. T cells from homozygous mutant animals lack gene expression and do not exhibit chemotaxis as assessed by RNase protection and chemotaxis assays, respectively. (J:65916)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcr3 Mutation: 14 strains or lines available

Notes

ES cell line = ES-1.

References

• Original: J:65916 Hancock WW, et al., Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med. 2000 Nov 20;192(10):1515-20
• All: 105 reference(s)