Cd19^tm1Tft
Targeted Allele Detail

Summary

• Symbol: Cd19^tm1Tft
• Name: CD19 antigen; targeted mutation 1, Thomas F Tedder
• MGI ID: MGI:2180685
• Synonyms: CD19-
• Gene: Cd19 Location: Chr7:126007622-126014061 bp, - strand Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
• Alliance: Cd19^tm1Tft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27236
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 encoding the transmembrane domain and 7 of the 9 exons encoding cytoplamic domains were replaced with a neomycin cassette. In addition, the inserted neomycin gene introduced a stop codon. Immunohistochemical staining showed a lack of protein expression in the spleens of homozygous mutant mice. (J:27236, J:100523)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd19 Mutation: 60 strains or lines available

References

• Original: J:27236 Engel P, et al., Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity. 1995 Jul;3(1):39-50
• All: 34 reference(s)