Cd22^tm1Lam
Targeted Allele Detail

Summary

• Symbol: Cd22^tm1Lam
• Name: CD22 antigen; targeted mutation 1, Marinus C Lamers
• MGI ID: MGI:2180698
• Synonyms: CD22-
• Gene: Cd22 Location: Chr7:30564829-30579767 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Cd22^tm1Lam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38644
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 11, encoding the transmembrane domain, was disrupted by the insertion of a neomycin cassette. Flow cytometric analysis showed an absence of surface expression on splenocytes isolated from homozygous mutant mice. (J:38644)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd22 Mutation: 64 strains or lines available

References

• Original: J:38644 Nitschke L, et al., CD22 is a negative regulator of B-cell receptor signalling. Curr Biol. 1997 Feb 1;7(2):133-43
• All: 27 reference(s)