Cd22^tm1Msn
Targeted Allele Detail

Summary

• Symbol: Cd22^tm1Msn
• Name: CD22 antigen; targeted mutation 1, Michael S Neuberger
• MGI ID: MGI:2180701
• Synonyms: CD22-
• Gene: Cd22 Location: Chr7:30564829-30579767 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Cd22^tm1Msn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76974
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the transmembrane domain was replaced by a neomycin cassette. Flow cytometric analyis showed a lack of protein expression on the surface of splenic B cells isolated from homozygous mutant mice. (J:76974)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd22 Mutation: 64 strains or lines available

References

• Original: J:76974 O'Keefe TL, et al., Hyperresponsive B cells in CD22-deficient mice. Science. 1996 Nov 1;274(5288):798-801
• All: 8 reference(s)