Pik3cb^tm1Nbm
Targeted Allele Detail

Summary

• Symbol: Pik3cb^tm1Nbm
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1, Robert L Nussbaum
• MGI ID: MGI:2180703
• Synonyms: p110beta^-, Pik3cb^del
• Gene: Pik3cb Location: Chr9:98920455-99022264 bp, - strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Pik3cb^tm1Nbm page

Phase contrast microscopy of blastobysts flushed at day 3.5 d.p.c.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75617
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons spanning nucleotides 2943-3180 were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event deletes 79 amino acids from position 982-1060 forming 28% of the phosphoinositol 3-kinase catalytic domain. (J:75617)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cb Mutation: 152 strains or lines available

References

• Original: J:75617 Bi L, et al., Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome. 2002 Mar;13(3):169-72
• All: 4 reference(s)