Cd1d1^tm1Luc
Targeted Allele Detail

Summary

• Symbol: Cd1d1^tm1Luc
• Name: CD1d1 antigen; targeted mutation 1, Luc Van Kaer
• MGI ID: MGI:2180711
• Synonyms: CD1-, cD1d-, CD1d⁰, CD1d1^-, CD1d1⁰
• Gene: Cd1d1 Location: Chr3:86903141-86906748 bp, - strand Genetic Position: Chr3, 37.91 cM
• Alliance: Cd1d1^tm1Luc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39748
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin selection cassette replaced 200 nucleotides in exon 3 of Cd1d1, while leaving the adjacent Cd1d2 locus intact. Thymocytes derived from homozygous mutant mice were shown to lack protein surface expression. This finding was confirmed by the inability of a specific hybridoma to recognize thymocytes from homozygous mutant mice. (J:39748)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cd1d1^tm1Luc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cd1d1 Mutation: 35 strains or lines available

References

• Original: J:39748 Mendiratta SK, et al., CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997 APR;6(4):469-477
• All: 135 reference(s)