Tcra-J^tm1Tgi
Targeted Allele Detail

Summary

• Symbol: Tcra-J^tm1Tgi
• Name: T cell receptor alpha, joining region; targeted mutation 1, Masaru Taniguchi
• MGI ID: MGI:2180736
• Synonyms: JA18^-, Ja18⁰, Jalpha18-, Jalpha18^-, Jalpha18-KO, Jalpha18KO, Jalpha281-, Jalpha281 KO, Jalpha281KO, NK T KO, NKT-KO, TCR Jalpha18^-, Valpha14 NKT-KO
• Gene: Tcra-J Location: unknown Genetic Position: Chr14, Syntenic

Il17rb^tm1Tgi/Il17rb^tm1Tgi and Tcra-J^tm1Tgi/Tcra-J^tm1Tgi mice fail to exhibit airway hyperactivity in response to respiratory syncytial virus exposure

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76989
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire sequence of the endogenous locus was replaced with a neomycin selection cassette inserted by homologous recombination. An absence of transcipt in homozygous mutant mice was determined by RNAse protection. (J:76989)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tcra-J^tm1Tgi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcra-J Mutation: 0 strains or lines available

References

• Original: J:76989 Cui J, et al., Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science. 1997 Nov 28;278(5343):1623-6
• All: 319 reference(s)