Igdcc3^tm1Sms
Targeted Allele Detail

Summary

• Symbol: Igdcc3^tm1Sms
• Name: immunoglobulin superfamily, DCC subclass, member 3; targeted mutation 1, Suzanne L Mansour
• MGI ID: MGI:2180750
• Synonyms: punc^LN
• Gene: Igdcc3 Location: Chr9:65048471-65093154 bp, + strand Genetic Position: Chr9, 35.13 cM, cytoband D-E1
• Alliance: Igdcc3^tm1Sms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70796
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo-lacZ cassette into exon 2 via homologous recombination, which introduces stop codons into all 3 reading frames. LoxP sites flank the PGK-neo portion of the targeting vector. Northern blot analysis of E11.5 homozygous mutant embryos did not detect gene transcripts. RT-PCR detected very low amounts of mutant transcripts thought to originate within the lacZ gene. (J:70796)

Expression

In Mice Carrying this Mutation:

85 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igdcc3 Mutation: 19 strains or lines available

References

• Original: J:70796 Yang W, et al., Impaired motor coordination in mice that lack punc. Mol Cell Biol. 2001 Sep;21(17):6031-43
• All: 1 reference(s)