Pirb^tm1Ttk
Targeted Allele Detail

Summary

• Symbol: Pirb^tm1Ttk
• Name: paired Ig-like receptor B; targeted mutation 1, Toshiyuki Takai
• MGI ID: MGI:2180757
• Synonyms: PIR-B-
• Gene: Pirb Location: Chr7:3715504-3723381 bp, - strand Genetic Position: Chr7, 2.14 cM
• Alliance: Pirb^tm1Ttk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76770
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a neomycin cassette via homologous recombination resulting in the deletion of the sixth ectodomain and juxtamembrane domains. Western blot analysis of splenic B cells from homozygous mutant animals verified the absence of protein product. (J:76770)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pirb Mutation: 65 strains or lines available

References

• Original: J:76770 Ujike A, et al., Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice. Nat Immunol. 2002 Jun;3(6):542-8
• All: 30 reference(s)