Ppp1r1a^tm1Pba
Targeted Allele Detail

Summary

• Symbol: Ppp1r1a^tm1Pba
• Name: protein phosphatase 1, regulatory inhibitor subunit 1A; targeted mutation 1, Patrick B Allen
• MGI ID: MGI:2180759
• Synonyms: I-1-
• Gene: Ppp1r1a Location: Chr15:103438706-103446430 bp, - strand Genetic Position: Chr15, 59.01 cM, cytoband F
• Alliance: Ppp1r1a^tm1Pba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76892
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance gene via homologous recombination. Western blot analysis of hippocampal extracts from homozygous mutant animals verified the absence of gene expression. (J:76892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r1a Mutation: 25 strains or lines available

References

• Original: J:76892 Allen PB, et al., Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms. J Neurosci. 2000 May 15;20(10):3537-43
• All: 10 reference(s)