Cd3dtm1Kap
Targeted Allele Detail
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Symbol: |
Cd3dtm1Kap |
Name: |
CD3 antigen, delta polypeptide; targeted mutation 1, Dietmar J Kappes |
MGI ID: |
MGI:2180760 |
Synonyms: |
CD3delta-deficient, delta- |
Gene: |
Cd3d Location: Chr9:44893067-44898350 bp, + strand Genetic Position: Chr9, 24.84 cM
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Alliance: |
Cd3dtm1Kap page
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Germline Transmission: |
Earliest citation of germline transmission:
J:39925
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2, which encodes most of the protein, was replaced with a neomycin selection cassette. RT-PCR and Northern blot analyses of homozygous mutant mice indicated an absence of normal transcript. Aberrant transcripts were reported. Normal levels of Cd3e and Cd3g transcript were detected.
(J:39925)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd3d Mutation: |
29 strains or lines available
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Original: |
J:39925 Dave VP, et al., CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J. 1997 Mar 17;16(6):1360-70 |
All: |
10 reference(s) |
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