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Cd3dtm1Kap
Targeted Allele Detail
Summary
Symbol: Cd3dtm1Kap
Name: CD3 antigen, delta polypeptide; targeted mutation 1, Dietmar J Kappes
MGI ID: MGI:2180760
Synonyms: CD3delta-deficient, delta-
Gene: Cd3d  Location: Chr9:44893067-44898350 bp, + strand  Genetic Position: Chr9, 24.84 cM
Alliance: Cd3dtm1Kap page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39925
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which encodes most of the protein, was replaced with a neomycin selection cassette. RT-PCR and Northern blot analyses of homozygous mutant mice indicated an absence of normal transcript. Aberrant transcripts were reported. Normal levels of Cd3e and Cd3g transcript were detected. (J:39925)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd3d Mutation:  29 strains or lines available
References
Original:  J:39925 Dave VP, et al., CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J. 1997 Mar 17;16(6):1360-70
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory