Del(9Cd3g-Cd3d)1Cpt
Targeted Allele Detail

Summary

• Symbol: Del(9Cd3g-Cd3d)1Cpt
• Name: deletion, Chr 9, Cox Terhorst 1
• MGI ID: MGI:2180768
• Synonyms: Cd3d/Cd3g^tm1Cpt, CD3gammadelta^-
• Gene: Del(9Cd3g-Cd3d)1Cpt Location: unknown Genetic Position: Chr9, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76991
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(9Cd3g-Cd3d)1Cpt involves 2 genes/genome features (Cd3g, Cd3d) View all
• Mutation details: The adjacent Cd3d and the Cd3g loci are arranged in a head-to-head fashion enabling the targeting of exon 1 from each locus with a single hygromycin cassette. Northern analysis of thymocytes isolated from homozygous mice showed an absence of transcript from both loci. Expression of the related Cd3e and Cd3z genes was observed, though at levels above and below normal, respectively. (J:76991)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(9Cd3g-Cd3d)1Cpt Mutation: 0 strains or lines available

References

• Original: J:76991 Wang B, et al., Essential and partially overlapping role of CD3gamma and CD3delta for development of alphabeta and gammadelta T lymphocytes. J Exp Med. 1998 Oct 5;188(7):1375-80
• All: 6 reference(s)