Cd48^tm1Rsr
Targeted Allele Detail

Summary

• Symbol: Cd48^tm1Rsr
• Name: CD48 antigen; targeted mutation 1, Hans Reiser
• MGI ID: MGI:2180770
• Synonyms: CD48^-
• Gene: Cd48 Location: Chr1:171509577-171532826 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Cd48^tm1Rsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53718
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the exon encoding the immunoglobulin-V-like domain, which forms a binding site for the Cd2 antigen. Thymocytes and splenocytes isolated from homozygous mutant mice were found to lack surface expression of the endogenous protien. (J:53718)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd48 Mutation: 23 strains or lines available

References

• Original: J:53718 Gonzalez-Cabrero J, et al., CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1019-23
• All: 6 reference(s)