Tnp2^tm1Wen
Targeted Allele Detail

Summary

• Symbol: Tnp2^tm1Wen
• Name: transition protein 2; targeted mutation 1, Wolfgang Engel
• MGI ID: MGI:2180779
• Synonyms: Tnp2^-/-
• Gene: Tnp2 Location: Chr16:10605799-10606519 bp, - strand Genetic Position: Chr16, 5.83 cM, cytoband B1-B3
• Alliance: Tnp2^tm1Wen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76986
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 1 upstream of the argnine- and lysine-rich domain via homologous recombination. Northern and Western blot of testes from homozygous mutant mice verified the absence of gene expression. (J:76986)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnp2 Mutation: 5 strains or lines available

References

• Original: J:76986 Adham IM, et al., Teratozoospermia in mice lacking the transition protein 2 (Tnp2). Mol Hum Reprod. 2001 Jun;7(6):513-20
• All: 4 reference(s)