Cdh4^tm1Semb
Targeted Allele Detail

Summary

• Symbol: Cdh4^tm1Semb
• Name: cadherin 4; targeted mutation 1, Henrik Semb
• MGI ID: MGI:2180782
• Synonyms: R-cadherin^-
• Gene: Cdh4 Location: Chr2:179084228-179541166 bp, + strand Genetic Position: Chr2, 101.86 cM
• Alliance: Cdh4^tm1Semb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74658
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette replaced exon 1 and exon 2. An absence of transcript in kidneys isolated from homozygous mutant embryos was determined via Northern blot analysis using probes for the 5' terminal, middle, and 3' terminal of the endogenous cDNA. Immunoblotting of brain extracts showed a lack of protein. (J:74658)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh4 Mutation: 56 strains or lines available

References

• Original: J:74658 Dahl U, et al., Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol. 2002 Mar;22(5):1474-87
• All: 1 reference(s)