Cd72^tm1Jrp
Targeted Allele Detail

Summary

• Symbol: Cd72^tm1Jrp
• Name: CD72 antigen; targeted mutation 1, Jane R Parnes
• MGI ID: MGI:2180786
• Synonyms: CD72^-
• Gene: Cd72 Location: Chr4:43447724-43454708 bp, - strand Genetic Position: Chr4, 23.04 cM
• Alliance: Cd72^tm1Jrp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76990
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.1kb fragment containing the minimal promoter and exons 1 through 4, encoding the cytoplasmic and transmembrane domains, was deleted by the insertion of a PGK-neo cassette. A lack of cell surface protein expression was determined by flow cytometric analysis of splenocytes isolated from homozygous mutant mice. (J:76990)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd72 Mutation: 30 strains or lines available

References

• Original: J:76990 Pan C, et al., CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity. 1999 Oct;11(4):495-506
• All: 5 reference(s)