Comp^tm1Aol
Targeted Allele Detail

Summary

• Symbol: Comp^tm1Aol
• Name: cartilage oligomeric matrix protein; targeted mutation 1, Ake Oldberg
• MGI ID: MGI:2180787
• Synonyms: COMP-null, TSP5 KO
• Gene: Comp Location: Chr8:70826208-70834716 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Comp^tm1Aol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76781
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette via homologous recombination into sequences encoding the first type 3 repeat. Northern blot, RT-PCR analysis, and Western blot of RNA and proteins extracted from the processus xiphoideus of homozygous mutant mice verified the absence of gene expression. (J:76781)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Comp Mutation: 37 strains or lines available

References

• Original: J:76781 Svensson L, et al., Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol. 2002 Jun;22(12):4366-71
• All: 17 reference(s)