Cdc25c^tm1Hpw
Targeted Allele Detail

Summary

• Symbol: Cdc25c^tm1Hpw
• Name: cell division cycle 25C; targeted mutation 1, Helen Piwnica-Worms
• MGI ID: MGI:2180791
• Synonyms: Cdc25C^-
• Gene: Cdc25c Location: Chr18:34866046-34884586 bp, - strand Genetic Position: Chr18, 18.71 cM
• Alliance: Cdc25c^tm1Hpw page

Shortened villi in the small intestine of Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ (TKO) mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69601
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a neomycin resistance gene. Northern blot analysis of total testicular RNA showed the exclusive presence of a longer transcript, containing the neo transgene, in extracts from homozygous mutant mice. Western blot analysis of MEF lysates derived from homozygous mutant animals showed an absence of encoded protein using various antibodies. (J:69601)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdc25c Mutation: 23 strains or lines available

References

• Original: J:69601 Chen MS, et al., Absence of apparent phenotype in mice lacking cdc25c protein phosphatase. Mol Cell Biol. 2001 Jun;21(12):3853-61
• All: 6 reference(s)