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Cd9tm1Kudo
Targeted Allele Detail
Summary
Symbol: Cd9tm1Kudo
Name: CD9 antigen; targeted mutation 1, Akira Kudo
MGI ID: MGI:2180798
Synonyms: Cd9-
Gene: Cd9  Location: Chr6:125437229-125471723 bp, - strand  Genetic Position: Chr6, 59.32 cM
Alliance: Cd9tm1Kudo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60753
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which encodes the first transmembrane domain, was replaced with a neomycin resistance gene. Sequenc analysis of a transcript present in mutant mice showed that exon 1 had spliced to exon 3 causing a frameshift mutation that introduced a stop codon in exon 3. While a cytoplasmic domain may have been produced, flow cytometric analysis of bone marrow macrophages showed no cell surface protein expression. (J:60753)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd9 Mutation:  104 strains or lines available
References
Original:  J:60753 Kaji K, et al., The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet. 2000 Mar;24(3):279-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory