Cd9tm1Kudo
Targeted Allele Detail
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Symbol: |
Cd9tm1Kudo |
Name: |
CD9 antigen; targeted mutation 1, Akira Kudo |
MGI ID: |
MGI:2180798 |
Synonyms: |
Cd9- |
Gene: |
Cd9 Location: Chr6:125437229-125471723 bp, - strand Genetic Position: Chr6, 59.32 cM
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Alliance: |
Cd9tm1Kudo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:60753
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2, which encodes the first transmembrane domain, was replaced with a neomycin resistance gene. Sequenc analysis of a transcript present in mutant mice showed that exon 1 had spliced to exon 3 causing a frameshift mutation that introduced a stop codon in exon 3. While a cytoplasmic domain may have been produced, flow cytometric analysis of bone marrow macrophages showed no cell surface protein expression.
(J:60753)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd9 Mutation: |
104 strains or lines available
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Original: |
J:60753 Kaji K, et al., The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet. 2000 Mar;24(3):279-82 |
All: |
1 reference(s) |
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