About   Help   FAQ
Cd9tm1Kudo
Targeted Allele Detail
Summary
Symbol: Cd9tm1Kudo
Name: CD9 antigen; targeted mutation 1, Akira Kudo
MGI ID: MGI:2180798
Synonyms: Cd9-
Gene: Cd9  Location: Chr6:125437229-125471723 bp, - strand  Genetic Position: Chr6, 59.32 cM
Alliance: Cd9tm1Kudo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60753
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which encodes the first transmembrane domain, was replaced with a neomycin resistance gene. Sequenc analysis of a transcript present in mutant mice showed that exon 1 had spliced to exon 3 causing a frameshift mutation that introduced a stop codon in exon 3. While a cytoplasmic domain may have been produced, flow cytometric analysis of bone marrow macrophages showed no cell surface protein expression. (J:60753)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd9 Mutation:  104 strains or lines available
References
Original:  J:60753 Kaji K, et al., The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet. 2000 Mar;24(3):279-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory