Kif1c^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Kif1c^tm1Noh
• Name: kinesin family member 1C; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:2180803
• Synonyms: kif1C-
• Gene: Kif1c Location: Chr11:70591374-70622790 bp, + strand Genetic Position: Chr11, 43.21 cM
• Alliance: Kif1c^tm1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73969
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette consisting of a splice acceptor site, an internal ribosomal entry site (IRES), and a lacZ-neomycin resistance gene fusion replaced 2.6 kb of sequence encoding the ATP binding motif P-loop. The cassette was inserted downstream of the ATG-containing exon. A beta-galactosidase fusion protein is expressed from this allele. Immunoblot analysis using a polyclonal antibody against a C-terminal peptide sequence did not detect wild-type protein in brain from homozygous mutant mice. (J:73969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif1c Mutation: 33 strains or lines available

References

• Original: J:73969 Nakajima K, et al., Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport. Mol Cell Biol. 2002 Feb;22(3):866-73
• All: 2 reference(s)