Cd81^tm1Geha
Targeted Allele Detail

Summary

• Symbol: Cd81^tm1Geha
• Name: CD81 antigen; targeted mutation 1, Raif S Geha
• MGI ID: MGI:2180813
• Gene: Cd81 Location: Chr7:142606487-142621667 bp, + strand Genetic Position: Chr7, 88.1 cM
• Alliance: Cd81^tm1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43975
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 2 through 8, comprising the majority of the coding sequence. FACS analysis showed a lack of cell surface protein expression on thymocytes isolated from homozygous mutant mice. (J:43975)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd81 Mutation: 22 strains or lines available

References

• Original: J:43975 Tsitsikov EN, et al., Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10844-9
• All: 4 reference(s)