Cebpg^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Cebpg^tm1Aki
• Name: CCAAT/enhancer binding protein gamma; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2180824
• Synonyms: C/EBPgamma^-
• Gene: Cebpg Location: Chr7:34745847-34755991 bp, - strand Genetic Position: Chr7, 20.91 cM
• Alliance: Cebpg^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58801
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2, encoding the DNA binding and leucine zipper domains, was disrupted by the insertion of a neomycin selection cassette. RT-PCR analysis showed a lack of transcript in total RNA extracts from the spleens and livers of homozygous mutant mice. (J:58801)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpg Mutation: 9 strains or lines available

References

• Original: J:58801 Kaisho T, et al., Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice. J Exp Med. 1999 Dec 6;190(11):1573-82
• All: 3 reference(s)