Fgf2^tm1Bee
Targeted Allele Detail

Summary

• Symbol: Fgf2^tm1Bee
• Name: fibroblast growth factor 2; targeted mutation 1, Friedrich Beerman
• MGI ID: MGI:2180834
• Synonyms: FGF2-, Fgf2^tm1Siec
• Gene: Fgf2 Location: Chr3:37402616-37464255 bp, + strand Genetic Position: Chr3, 18.41 cM, cytoband A2-B
• Alliance: Fgf2^tm1Bee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75629
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 of the gene was replaced with a PGK-neo-lacZ cassette via homologous recombination. RT-PCR analysis demonstrated the absence of mRNA in lung and kidney from homozygous mutant animals. (J:75629)

Tumor Data

List all tumor models in MMHCdb carrying Fgf2^tm1Bee

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf2 Mutation: 19 strains or lines available

References

• Original: J:75629 Foletti A, et al., Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE. Oncogene. 2002 Mar 14;21(12):1841-7
• All: 4 reference(s)