Cebpd^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Cebpd^tm1Aki
• Name: CCAAT/enhancer binding protein delta; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2180837
• Synonyms: C/EBPdelta(-)
• Gene: Cebpd Location: Chr16:15705150-15707409 bp, + strand Genetic Position: Chr16, 10.09 cM
• Alliance: Cebpd^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45062
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the region encoding the promoter region, transcription start site, and the transactivation domain. Northern blot analysis of total RNA isolated from the lungs of homozygous mutant mice showed an absence of transcript. (J:45062)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpd Mutation: 9 strains or lines available

References

• Original: J:45062 Tanaka T, et al., Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J. 1997 Dec 15;16(24):7432-43
• All: 4 reference(s)