Cebpd^tm1Pfj
Targeted Allele Detail

Summary

• Symbol: Cebpd^tm1Pfj
• Name: CCAAT/enhancer binding protein delta; targeted mutation 1, Peter F Johnson
• MGI ID: MGI:2180841
• Synonyms: C/EBPdelta^-, C/EBPdelta-KO
• Gene: Cebpd Location: Chr16:15705150-15707409 bp, + strand Genetic Position: Chr16, 10.09 cM
• Alliance: Cebpd^tm1Pfj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49799
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single exon containing the entire coding region was replaced by a neomycin selection cassette. An absence of transcript in kidney and hippocampal tissue isolated from homozygous mutant mice was determined by Northern blot analysis. (J:49799)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpd Mutation: 9 strains or lines available

Notes

mRNA expression of Slc5a8 and Slc5a12 is undetectable in the kidneys of these mice, although expression appears normal in non-renal tissues (J:116932).

References

• Original: J:49799 Sterneck E, et al., Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10908-13
• All: 33 reference(s)