Itga4^tm1Jty
Targeted Allele Detail

Summary

• Symbol: Itga4^tm1Jty
• Name: integrin alpha 4; targeted mutation 1, Joy T Yang
• MGI ID: MGI:2180843
• Synonyms: alpha4KI-lacZ
• Gene: Itga4 Location: Chr2:79085770-79163467 bp, + strand Genetic Position: Chr2, 47.38 cM
• Alliance: Itga4^tm1Jty page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76747
• Parent Cell Line: MC3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 91 bp of exon 1 was replaced with a PGK-neo-lacZ reporter cassette via homologous recombination resulting in the deletion of 22 of 39 signal peptide residues and 8 residues from the amino terminus of the mature protein. Homozygous mutant embryos were identified by PCR analysis. (J:76747)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga4 Mutation: 62 strains or lines available

References

• Original: J:76747 Sengbusch JK, et al., Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol. 2002 May 27;157(5):873-82
• All: 2 reference(s)