Cenpc1^tm1Khac
Targeted Allele Detail

Summary

• Symbol: Cenpc1^tm1Khac
• Name: centromere protein C1; targeted mutation 1, K H Andy Choo
• MGI ID: MGI:2180846
• Gene: Cenpc1 Location: Chr5:86159883-86213442 bp, - strand Genetic Position: Chr5, 43.56 cM, cytoband E2-E5
• Alliance: Cenpc1^tm1Khac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45656
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct containing a beta-geo fusion marker as well as a splice-acceptor site and a picornaviral internal ribosome-entry site (IRES) was inserted upstream of exon 8 and 9. The construct was designed to prevent the translation of the functionally essential centromere targeting region. Southern blot analysis confirmed the targeting event. (J:45656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cenpc1 Mutation: 46 strains or lines available

References

• Original: J:45656 Kalitsis P, et al., Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1136-41
• All: 1 reference(s)