Cel^tm1Dyh
Targeted Allele Detail

Summary

• Symbol: Cel^tm1Dyh
• Name: carboxyl ester lipase; targeted mutation 1, David Y Hui
• MGI ID: MGI:2180867
• Synonyms: CEL(-)
• Gene: Cel Location: Chr2:28445831-28453415 bp, - strand Genetic Position: Chr2, 19.38 cM
• Alliance: Cel^tm1Dyh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32099
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 4 was disrupted by the insertion of a neomycin resistance gene. The disruption occurred immediately upstream of the active site domains and precludes the processing of exon 11, which is essential for secretion of the protein from the pancreas. Western blot analysis of pancreatic homogenates from homozygous mutant mice showed an absence of protein product, truncated or otherwise. (J:32099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cel Mutation: 32 strains or lines available

References

• Original: J:32099 Howles PN, et al., Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. J Biol Chem. 1996 Mar 22;271(12):7196-202
• All: 6 reference(s)