Cel^tm1Eaf
Targeted Allele Detail

Summary

• Symbol: Cel^tm1Eaf
• Name: carboxyl ester lipase; targeted mutation 1, Edward A Fisher
• MGI ID: MGI:2180869
• Synonyms: BSDL^-, BSSL^-, CELKO
• Gene: Cel Location: Chr2:28445831-28453415 bp, - strand Genetic Position: Chr2, 19.38 cM
• Alliance: Cel^tm1Eaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54090
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter and exons 1 through 3 were replaced with a neomycin selection cassette. Enzymatic activity was undetectable via radiometric analysis of the pancreas, breast milk, and plasma of homozygous mutant mice.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cel Mutation: 32 strains or lines available

References

• Original: J:54090 Weng W, et al., Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout mice. Biochemistry. 1999 Mar 30;38(13):4143-9
• All: 4 reference(s)