Sim2^tm1Fan
Targeted Allele Detail

Summary

• Symbol: Sim2^tm1Fan
• Name: single-minded family bHLH transcription factor 2; targeted mutation 1, Chen-Ming Fan
• MGI ID: MGI:2180881
• Gene: Sim2 Location: Chr16:93885963-93927891 bp, + strand Genetic Position: Chr16, 55.05 cM, cytoband C3.3-C4
• Alliance: Sim2^tm1Fan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76787
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 422 bp of the 5' untranslated region and the first 144 bp of the gene coding region were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the first 48 amino acids of the basic helix-loop-helix domain. Gene expression is absent in kidneys from homozygous mutant animals as determined by in situ hybridization. (J:76787)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sim2 Mutation: 23 strains or lines available

References

• Original: J:76787 Goshu E, et al., Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol Cell Biol. 2002 Jun;22(12):4147-57
• All: 5 reference(s)