Krt10^tm1Tmm
Targeted Allele Detail

Summary

• Symbol: Krt10^tm1Tmm
• Name: keratin 10; targeted mutation 1, Thomas M Magin
• MGI ID: MGI:2180882
• Gene: Krt10 Location: Chr11:99276080-99280190 bp, - strand Genetic Position: Chr11, 62.92 cM
• Alliance: Krt10^tm1Tmm page

Krt10^tm1Tmm/Krt10^tm1Tmm mice show large areas of skin loss while Krt10^tm1Tmm/Krt10⁺ mice show hyperkeratotic scaling of the skin

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31853
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 7 were replaced by an HPRT cassette. Northern analysis showed a lack of transcript in homozygous mutant mice. (J:31853)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Krt10 Mutation: 32 strains or lines available

References

• Original: J:31853 Porter RM, et al., Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis. J Cell Biol. 1996 Mar;132(5):925-36
• All: 6 reference(s)