Dclre1a^tm1Roka
Targeted Allele Detail

Summary

• Symbol: Dclre1a^tm1Roka
• Name: DNA cross-link repair 1A; targeted mutation 1, Roland Kanaar
• MGI ID: MGI:2180947
• Synonyms: SNM1 -
• Gene: Dclre1a Location: Chr19:56517599-56536675 bp, - strand Genetic Position: Chr19, 51.89 cM
• Alliance: Dclre1a^tm1Roka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62832
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was incorporated to delete part of intron 3 and 25 bp of exon 4. This targeting event resulted in the removal of the C-terminal 2876 amino acids which contain most of the conserved motifs. (J:62832)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dclre1a Mutation: 41 strains or lines available

References

• Original: J:62832 Dronkert ML, et al., Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C. Mol Cell Biol. 2000 Jul;20(13):4553-61
• All: 1 reference(s)