Plscr1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Plscr1^tm1Lex
• Name: phospholipid scramblase 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:2180949
• Synonyms: PLSCR1-
• Gene: Plscr1 Location: Chr9:92132265-92154034 bp, + strand Genetic Position: Chr9, 48.35 cM, cytoband E3.3
• Alliance: Plscr1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76790
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: Targeting was performed by Lexicon Genetics (The Woodlands, TX). No details have been provided other than that the targeting vector was constructed using a genomic DNA fragment containing exons 4 to 8 of the murine gene. Absence of gene transcript and protein product were confirmed by Northern and Western blot analysis. (J:76790)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Plscr1 Mutation: 28 strains or lines available

References

• Original: J:76790 Zhou Q, et al., Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1. Blood. 2002 Jun 1;99(11):4030-8
• All: 8 reference(s)