Ccr9^tm1.1Mal
Targeted Allele Detail

Summary

• Symbol: Ccr9^tm1.1Mal
• Name: C-C motif chemokine receptor 9; targeted mutation 1.1, Bernard Malissen
• MGI ID: MGI:2181004
• Synonyms: CCR9^-
• Gene: Ccr9 Location: Chr9:123596276-123612522 bp, + strand Genetic Position: Chr9, 74.33 cM, cytoband F
• Alliance: Ccr9^tm1.1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72386
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice possessing the Ccr9^tm1Mal allele were bred with mice ubiquitously expressing cre-recombinase to generate a locus that lacked exon 3 and the inserted floxed neomycin resistance gene cassette. Both an RT-PCR analysis and an RNase protection assay showed a lack of transcript in homozygous mutant thymus tissue. (J:72386)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr9 Mutation: 31 strains or lines available

References

• Original: J:72386 Wurbel MA, et al., Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes. Blood. 2001 Nov 1;98(9):2626-32
• All: 15 reference(s)