Ccr9^tm1.1Mal
Targeted Allele Detail

Summary

• Symbol: Ccr9^tm1.1Mal
• Name: C-C motif chemokine receptor 9; targeted mutation 1.1, Bernard Malissen
• MGI ID: MGI:2181004
• Synonyms: CCR9^-
• Gene: Ccr9 Location: Chr9:123596276-123612522 bp, + strand Genetic Position: Chr9, 74.33 cM, cytoband F
• Alliance: Ccr9^tm1.1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72386
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice possessing the Ccr9^tm1Mal allele were bred with mice ubiquitously expressing cre-recombinase to generate a locus that lacked exon 3 and the inserted floxed neomycin resistance gene cassette. Both an RT-PCR analysis and an RNase protection assay showed a lack of transcript in homozygous mutant thymus tissue. (J:72386)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ccr9^tm1.1Mal/Ccr9^tm1.1Mal	involves: 129S2/SvPas
hm2	Ccr9^tm1.1Mal/Ccr9^tm1.1Mal	involves: 129S2/SvPas * C57BL/6
cx3	Ccr9^tm1.1Mal/Ccr9^tm1.1Mal Tnf^tm2Gkl/Tnf^+	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Phenotypes:

Affected Systems	hm1	hm2	cx3
show or hide all annotated terms
digestive/alimentary system			√
intestinal inflammation			√
hematopoietic system	√	√	√
decreased pro-B cell number		√
abnormal T cell differentiation		√
abnormal leukocyte cell number		√
abnormal T cell subpopulation ratio	√		√
abnormal gamma-delta T cell number	√
decreased T cell number		√
decreased double-positive T cell number		√
decreased gamma-delta intraepithelial T cell number	√		√
increased T cell number		√
abnormal alpha-beta intraepithelial T cell morphology			√
immune system	√	√	√
intestinal inflammation			√
decreased pro-B cell number		√
abnormal T cell differentiation		√
abnormal leukocyte cell number		√
abnormal T cell subpopulation ratio	√		√
abnormal gamma-delta T cell number	√
decreased T cell number		√
decreased double-positive T cell number		√
decreased gamma-delta intraepithelial T cell number	√		√
increased T cell number		√
abnormal alpha-beta intraepithelial T cell morphology			√
abnormal mesenteric lymph node morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr9 Mutation: 31 strains or lines available

References

• Original: J:72386 Wurbel MA, et al., Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes. Blood. 2001 Nov 1;98(9):2626-32
• All: 15 reference(s)