Pex11b^tm1Sjg
Targeted Allele Detail

Summary

• Symbol: Pex11b^tm1Sjg
• Name: peroxisomal biogenesis factor 11 beta; targeted mutation 1, Stephen J Gould
• MGI ID: MGI:2181008
• Synonyms: PEX11beta-
• Gene: Pex11b Location: Chr3:96542692-96552682 bp, + strand Genetic Position: Chr3, 41.93 cM
• Alliance: Pex11b^tm1Sjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76782
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 were replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in liver of homozygous mutant animals as determined by Northern blot analysis. (J:76782)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pex11b Mutation: 14 strains or lines available

References

• Original: J:76782 Li X, et al., PEX11 beta deficiency is lethal and impairs neuronal migration but does not abrogate peroxisome function. Mol Cell Biol. 2002 Jun;22(12):4358-65
• All: 4 reference(s)