Sstr2^tm1Bne
Targeted Allele Detail

Summary

• Symbol: Sstr2^tm1Bne
• Name: somatostatin receptor 2; targeted mutation 1, Babraham Neuroendocrinology
• MGI ID: MGI:2181022
• Synonyms: Sstr2^-
• Gene: Sstr2 Location: Chr11:113510168-113516854 bp, + strand Genetic Position: Chr11, 79.05 cM
• Alliance: Sstr2^tm1Bne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75873
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene coding region was replaced with a lacZ-neo construct via homologous recombination. RT-PCR analysis confirmed the absence of gene expression in mutant animals. (J:75873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sstr2 Mutation: 33 strains or lines available

References

• Original: J:75873 Abdu F, et al., Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum. Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G624-33
• All: 1 reference(s)