Cnr2^tm1Zim
Targeted Allele Detail

Summary

• Symbol: Cnr2^tm1Zim
• Name: cannabinoid receptor 2; targeted mutation 1, Andreas Zimmer
• MGI ID: MGI:2181023
• Synonyms: CB2^-, CB2^tm1, CB2xP, CNR2^-
• Gene: Cnr2 Location: Chr4:135622705-135647518 bp, + strand Genetic Position: Chr4, 68.01 cM
• Alliance: Cnr2^tm1Zim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62417
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 341 nucleotides were deleted from the 3' end of the single exon and replaced with a neomycin selection cassette. The deleted region encoded a portion of the intracellular loop 3, transmembrane domains 6 and 7, and the C-terminus. Absence of ligand-binding in spleen sections and homogenates derived from homozygous mutant mice was determined by receptor autoradiography. In addition, binding studies of brain homogenates confirmed that the brain cannabinoid receptor was unaffected by the targeting event. (J:62417)

Tumor Data

List all tumor models in MMHCdb carrying Cnr2^tm1Zim

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cnr2 Mutation: 24 strains or lines available

References

• Original: J:62417 Buckley NE, et al., Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur J Pharmacol. 2000 May 19;396(2-3):141-9
• All: 85 reference(s)