Cntfr^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Cntfr^tm1Gdy
• Name: ciliary neurotrophic factor receptor; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:2181046
• Synonyms: CNTFRalpha^-
• Gene: Cntfr Location: Chr4:41657498-41697089 bp, - strand Genetic Position: Chr4, 21.81 cM
• Alliance: Cntfr^tm1Gdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29357
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Approximately 18-kb of sequence, containing exons 2 through 5, was replaced by a neomycin selection cassette. Normal transcipt was absent in a Northern blot of total brain mRNA from homozygous mutant mice, although a truncated peptide was detected. (J:29357)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cntfr Mutation: 53 strains or lines available

References

• Original: J:29357 DeChiara TM, et al., Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 1995 Oct 20;83(2):313-22
• All: 3 reference(s)