Cntf^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Cntf^tm1Gdy
• Name: ciliary neurotrophic factor; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:2181048
• Synonyms: CNTF^-
• Gene: Cntf Location: Chr19:12741024-12742996 bp, - strand Genetic Position: Chr19, 8.73 cM
• Alliance: Cntf^tm1Gdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29357
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 1 and 2. Western blot analysis showed an absence of encdoded protein in sciatic nerve extracts from homozygous mutant mice. (J:29357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cntf Mutation: 13 strains or lines available

References

• Original: J:29357 DeChiara TM, et al., Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 1995 Oct 20;83(2):313-22
• All: 2 reference(s)