Cntn2^tm1Fuka
Targeted Allele Detail

Summary

• Symbol: Cntn2^tm1Fuka
• Name: contactin 2; targeted mutation 1, Fumihiko Fukamauchi
• MGI ID: MGI:2181052
• Synonyms: TAG-1 (-)
• Gene: Cntn2 Location: Chr1:132437163-132470989 bp, - strand Genetic Position: Chr1, 57.42 cM
• Alliance: Cntn2^tm1Fuka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67556
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region between exon 2 and 5, encoding the translational start codon through the first Ig-like domain, was replaced by a neomycin selection cassette. Western blot analysis using antibodies raised against the amino and carboxyl terminals showed an absence of encoded protein in homozygous mutant mice. (J:67556)

Expression

In Mice Carrying this Mutation:

28 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cntn2 Mutation: 56 strains or lines available

References

• Original: J:67556 Fukamauchi F, et al., TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus. Biochem Biophys Res Commun. 2001 Feb 16;281(1):220-6
• All: 15 reference(s)