Bcar1^tm1Hhi
Targeted Allele Detail

Summary

• Symbol: Bcar1^tm1Hhi
• Name: breast cancer anti-estrogen resistance 1; targeted mutation 1, Hisamaru Hirai
• MGI ID: MGI:2181166
• Synonyms: Cas-deficient
• Gene: Bcar1 Location: Chr8:112437106-112470441 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Bcar1^tm1Hhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48967
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette disrupts exon 2, which encodes the SH3 domain. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. (J:48967, J:138258)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcar1 Mutation: 28 strains or lines available

References

• Original: J:48967 Honda H, et al., Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas [see comments]. Nat Genet. 1998 Aug;19(4):361-5
• All: 2 reference(s)