Cox6a2^tm1Djg
Targeted Allele Detail

Summary

• Symbol: Cox6a2^tm1Djg
• Name: cytochrome c oxidase subunit 6A2; targeted mutation 1, Daniel J Garry
• MGI ID: MGI:2181189
• Synonyms: VIaH-
• Gene: Cox6a2 Location: Chr7:127804607-127805538 bp, - strand Genetic Position: Chr7, 70.04 cM
• Alliance: Cox6a2^tm1Djg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75606
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region of exon 2 encoding 97 amino acids was replaced with a PGK-neo cassette. Northern blot analysis of heart and skeletal muscle showed that homozygous mutant mice lacked transcript. (J:75606)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cox6a2 Mutation: 8 strains or lines available

References

• Original: J:75606 Radford NB, et al., Cardiac dysfunction in mice lacking cytochrome-c oxidase subunit VIaH. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H726-33
• All: 3 reference(s)