Bmp4^tm3.1Blh
Targeted Allele Detail

Summary

• Symbol: Bmp4^tm3.1Blh
• Name: bone morphogenetic protein 4; targeted mutation 3.1, Brigid L Hogan
• MGI ID: MGI:2181190
• Synonyms: BMP4-fx, Bmp4^loxP-lacZ
• Gene: Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
• Alliance: Bmp4^tm3.1Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75136
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: This hypomorphic allele is a derivative of Bmp4^tm3Blh. LoxP sites were inserted flanking exons 3 and 4, and a promoterless lacZ gene was inserted 3' to the loxP insertions. An frt-flanked neomycin selection cassette that was inserted downstream of the lacZ gene was removed by Flpe mediated recombination in the final allele. (J:75136)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp4 Mutation: 23 strains or lines available

References

• Original: J:75136 Kulessa H, et al., Generation of a loxP flanked bmp4(loxP-lacZ) allele marked by conditional lacZ expression. Genesis. 2002 Feb;32(2):66-8
• All: 15 reference(s)