Crx^tm1Clc
Targeted Allele Detail

Summary

• Symbol: Crx^tm1Clc
• Name: cone-rod homeobox; targeted mutation 1, Constance L Cepko
• MGI ID: MGI:2181191
• Synonyms: Crx-
• Gene: Crx Location: Chr7:15599872-15613880 bp, - strand Genetic Position: Chr7, 8.6 cM
• Alliance: Crx^tm1Clc page

Outer retina microscopy of Crx^tm1Clc/Crx^tm1Clc mice

Show the 10 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58796
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The homeodomain coding region containing exon 3 and a portion of exon 4 was replaced by a neomycin selection cassette. RT-PCR analysis showed an absence of transcript in the retinas of homozygous mutant mice. (J:58796)

Disease models

Expression

In Mice Carrying this Mutation:	12 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Crx Mutation: 27 strains or lines available

References

• Original: J:58796 Furukawa T, et al., Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet. 1999 Dec;23(4):466-70
• All: 33 reference(s)