Csf1r^tm1Ers
Targeted Allele Detail

Summary

• Symbol: Csf1r^tm1Ers
• Name: colony stimulating factor 1 receptor; targeted mutation 1, E Richard Stanley
• MGI ID: MGI:2181194
• Synonyms: Csf1r^-, fms^EGFP
• Gene: Csf1r Location: Chr18:61238644-61264211 bp, + strand Genetic Position: Chr18, 34.41 cM, cytoband D
• Alliance: Csf1r^tm1Ers page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73663
• Parent Cell Line: ESVJ-1182 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of an in-frame cassette containing a humanized green fluorescent protein sequence and a neomycin resistance gene. While annulment of the allele in mutant mice was indicated by Western blot analysis of bone-marrow derived macrophages, expression of the green fluorescent protein could not be detected by fluorescence microscopy or flow cytometry. (J:73663)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf1r Mutation: 67 strains or lines available

References

• Original: J:73663 Dai XM, et al., Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002 Jan 1;99(1):111-20
• All: 30 reference(s)