Calb1^tm2.1Mpin
Targeted Allele Detail

Summary

• Symbol: Calb1^tm2.1Mpin
• Name: calbindin 1; targeted mutation 2.1, Max-Planck-Institute for Neurobiology
• MGI ID: MGI:2181196
• Synonyms: Calb^tm2
• Gene: Calb1 Location: Chr4:15881264-15906709 bp, + strand Genetic Position: Chr4, 6.66 cM
• Alliance: Calb1^tm2.1Mpin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75111
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The first exon was flanked by a single loxP site 5' to the exon, and a loxP flanked neomycin selection cassette was inserted 3' to the exon. A Cre expression plasmid was used to remove the neomycin cassette. (J:75111)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Calb1 Mutation: 28 strains or lines available

References

• Original: J:75111 Barski JJ, et al., Conditional inactivation of the calbindin D-28k (Calb1) gene by Cre/loxP-mediated recombination. Genesis. 2002 Feb;32(2):165-8
• All: 4 reference(s)