Cry1^tm1Jhjh
Targeted Allele Detail

Summary

• Symbol: Cry1^tm1Jhjh
• Name: cryptochrome circadian regulator 1; targeted mutation 1, Jan J H Hoeijmakers
• MGI ID: MGI:2181205
• Synonyms: cry1-, mCry1-
• Gene: Cry1 Location: Chr10:84967564-85020918 bp, - strand Genetic Position: Chr10, 41.63 cM, cytoband C
• Alliance: Cry1^tm1Jhjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54241
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced coding sequence corresponding to base pairs 730 through 1479 in the cDNA sequence. RT-PCR followed by Southern blot analysis, using the complete cDNA as a probe, confirmed a lack of transcript in homozygous mutant mice. (J:54241)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cry1 Mutation: 36 strains or lines available

References

• Original: J:54241 van der Horst GT, et al., Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms [see comments]. Nature. 1999 Apr 15;398(6728):627-30
• All: 67 reference(s)