Cry2^tm1Asn
Targeted Allele Detail

Summary

• Symbol: Cry2^tm1Asn
• Name: cryptochrome circadian regulator 2; targeted mutation 1, Aziz Sancar
• MGI ID: MGI:2181212
• Synonyms: Cry2-, mCry2-
• Gene: Cry2 Location: Chr2:92233991-92264388 bp, - strand Genetic Position: Chr2, 51.01 cM, cytoband E
• Alliance: Cry2^tm1Asn page

Retinal degeneration in Pde6b^rd1/Pde6b^rd1, and Pde6b^rd1/Pde6b^rd1 Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn mouse retinas

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51110
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 1.1-kb region encoding the FAD-binding domain. Northern blot analysis and in situ hybridization showed a lack of transcript and protein in homozygous mutant mice. (J:51110)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Cry2^tm1Asn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cry2 Mutation: 42 strains or lines available

References

• Original: J:51110 Thresher RJ, et al., Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science. 1998 Nov 20;282(5393):1490-4
• All: 67 reference(s)