Serpinf2^tm1Hrl
Targeted Allele Detail

Summary

• Symbol: Serpinf2^tm1Hrl
• Name: serine (or cysteine) peptidase inhibitor, clade F, member 2; targeted mutation 1, H Roger Lijnen
• MGI ID: MGI:2181226
• Synonyms: alpha-2-AP^-, alpha2-AP^-
• Gene: Serpinf2 Location: Chr11:75322562-75330327 bp, - strand Genetic Position: Chr11, 45.89 cM
• Alliance: Serpinf2^tm1Hrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54047
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced the entire coding region (exon 2 through the stop codon in exon 10). RT-PCR analaysis of kidney and liver tissue showed an absence of transcript in homozygous mutant mice. Western blot analyses of unactivated and activated plasma confirmed a lack of encoded protein in homozygous mice. Complex formation was undetectable by blotting analysis of plasma incubated with purified plasmin. (J:43244, J:54047)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Serpinf2 Mutation: 26 strains or lines available

References

• Original: J:54047 Lijnen HR, et al., Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. Blood. 1999 Apr 1;93(7):2274-81
• All: 15 reference(s)