Tnfrsf11b^tm1Khs
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11b^tm1Khs
• Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); targeted mutation 1, Kanji Higashio
• MGI ID: MGI:2181227
• Synonyms: OCIF/OPG (-), OPG (-)
• Gene: Tnfrsf11b Location: Chr15:54114014-54141700 bp, - strand Genetic Position: Chr15, 21.15 cM
• Alliance: Tnfrsf11b^tm1Khs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48325
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a 1.3 kb PGK-neo cassette into exon 2 via homologous recombination. The insertion results in disruption of the cysteine-rich domains, which are involved in the biological activity of the protein. Homozygous mutant animals lacked gene transcription and protein product as determined by Northern and Western blot analyses. (J:48325)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11b Mutation: 31 strains or lines available

References

• Original: J:48325 Mizuno A, et al., Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun. 1998 Jun 29;247(3):610-5
• All: 32 reference(s)